The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein
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文摘
Hemilipin2 is heterodimeric secreted phospholipase A2 (sPLA2) purified from Hemiscorpius lepturus scorpion. Hemilipin2's large and small subunits have a molecular mass of 12866 and 2461 a.m.u. respectively. Hemilipin2’s large subunit has no homology with other sPLA2s group III. Hemilipin2 could form a subgroup of group III sPLA2. Hemilipin2 exhibits an anti-angiogenesis activity on cells migration, adhesion and vessel length, and in vivo on CAM model. The antiangiogenic effect appears to be independent from the catalytic activity and seemingly held by the small subunit.
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