Intermittent preventive antimalarial treatment to children (IPTc): firebreak or fire trap?

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• 作者：Pierre A. Buffet ; Valé ; rie Bri ; Laurent Ré ; nia ; Marc Thellier ; Martin Danis ; Dominique Mazier
• 刊名：Trends in Parasitology
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：24
• 期：11
• 页码：482-485
• 全文大小：106 K

文摘

Intermittent preventive treatment is the prescheduled administration of antimalarial drugs to at-risk patients in endemic areas. This approach, which is recommended for pregnant women, is being evaluated in children. Sulfadoxine–pyrimethamine plus amodiaquine recently proved to be more protective than artemisinin-containing regimens. Therefore, the use of artemisinin derivatives could potentially be restricted to symptomatic patients. Determinants of three pending issues: safety, efficacy throughout childhood, and effectiveness – the latter depending on the implementation of sustainable delivery mechanisms – are analyzed in this comment.