Poly(acrylic acid) conjugated hollow mesoporous carbon as a dual-stimuli triggered drug delivery system for chemo-photothermal synergistic therapy

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• 作者：Xian Li ; Chang Liu ; Shengyu Wang ; Jian Jiao ; Donghua Di ; Tongying Jiang ; Qinfu Zhao ; ^{zqf021110505@163.com} ; Siling Wang ; ^{silingwang@syphu.edu.cn}
• 关键词：Hollow mesoporous carbon ; Disulfide bonds ; Dual stimuli-responsive ; Photothermal therapy ; Poly(acrylic acid) ; Doxorubicin
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：594-603
• 全文大小：1676 K
• 卷排序：71

文摘

Poly(acrylic acid) was grafted on hollow mesoporous carbon (HMC) via disulfide bonds. The grafted PAA could increase the biocompatibility and stability of HMC. The DOX-loaded DOX/HMC-SS-PAA had a high drug loading efficiency up to 51.9%. DOX/HMC-SS-PAA showed redox/pH dual-responsive and NIR-triggered drug release. DOX/HMC-SS-PAA showed a chemo/photothermal synergistic therapy effect.