Cytotoxic dinorditerpenoids from Drypetes perreticulata

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• 作者：Ying-Zi Ge ; Hua Zhang ; Hong-Chun Liu ; Lei Dong ; Jian Ding ; Jian-Min Yue ; ^{jmyue@mail.shcnc.ac.cn" class="auth_mail}
• 关键词：Drypetes perreticulata ; Euphorbiaceae ; Dinorditerpenoid ; Dryperreins A&ndash ; D ; Cytotoxicity
• 刊名：Phytochemistry
• 出版年：April, 2014
• 年：2014
• 卷：100
• 期：Complete
• 页码：120-125
• 全文大小：762 K

文摘

Four hitherto unknown dinorditerpenoids, dryperreins A-D of the pimarane class, together with eight known triterpenoids, were isolated from twigs and leaves of Drypetes perreticulata. The structures of dryperreins A-D were elucidated on the basis of detailed spectroscopic analysis as (10S)-11,12-dihydroxy-6-methoxy-15,16-dinorpimara-5,8,11,13-tetraene-3,7-dione, (10S)-6,11,12-trihydroxy-15,16-dinorpimara-5,8,11,13-tetraene-3,7-dione, (10S)-11,12-dihydroxy-6-methoxy-15,16-dinorpimara-1,5,8,11,13-pentaene-3,7-dione, and (10S)-6,11,12-trihydroxy-15,16-dinorpimara-1,5,8,11,13-pentaene-3,7-dione, respectively. Dryperreins C and D exhibited strong cytotoxicity in vitro against HL-60 human tumor cell line. The structure-activity relationship of the cytotoxic compounds was briefly discussed.