CyLoP-1: Membrane-active peptide with cell-penetrating and antimicrobial properties

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• 作者：Nisha Ponnappan<sup>1sup> ; Deepthi Poornima Budagavi<sup>1sup> ; Archana Chugh<sup> ; sup><sup>achugh@bioschool.iitd.ac.insup>
• 关键词：AMP ; Antimicrobial peptide ; CFU ; Colony forming units ; CPP ; Cell-penetrating peptide ; CLSM ; Confocal laser scanning microscopy ; CPW ; Cell protoplast washing solution ; CyLoP-1 ; Cytosol localizing peptide-1 ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; Dimethyl sulfoxide ; FACS ; Fluorescence-activated cell sorter ; FBS ; Fetal bovine serum ; FDA ; Fluorescein diacetate ; FITC ; Fluorescein isothiocyanate ; GUS ; β-glucuronidase ; MAP ; Membrane-active peptide ; MRSA ; Methicillin-resistant Staphylococcus au
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1859
• 期：2
• 页码：167-176
• 全文大小：1105 K
• 卷排序：1859

文摘

Cell-penetrating ability and antimicrobial activity of cysteine rich peptide, CyLoP-1 in different cell types Cargo-delivery ability of CyLoP-1 in HeLa cells and wheat root tissues Selective killing of Methicillin-resistant Staphylococcus aureus by CyLoP-1 without causing toxicity to HeLa cells Importance of cysteine residues in the cell-penetrating and antimicrobial activity of the peptide