Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs

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Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs

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作者：P. Ojer^b ; ¹ ; ^{pojeroje@alumni.unav.es" class="auth_mail" title="E-mail the corresponding author} ; T. Iglesias^a ; ¹ ; ^{tiglesias@alumni.unav.es" class="auth_mail" title="E-mail the corresponding author} ; A. Azqueta^a ; ^{amazqueta@unav.es" class="auth_mail" title="E-mail the corresponding author} ; J.M. Irache^b ; ^{jmirache@unav.es" class="auth_mail" title="E-mail the corresponding author} ; A. Ló ; pez de Cerain^a ; ^{acerain@unav.es" class="auth_mail" title="E-mail the corresponding author}
关键词：ADME/PK ; absorption ; distribution ; metabolism ; excretion ; and pharmacokinetics ; ATP ; adenosine triphosphate ; B ; biocompatibility ; BCS ; Biopharmaceutics Classification System ; CS ; chitosan ; CTX ; ceftriaxone sodium ; DCFA ; 2&prime ; 7&prime ; -dichlorofluorescein diacetate ; EURL-ECVAM ; European Union Reference Laboratory for Alternatives to Animal Testing ; FAE ; follicle associated epithelia ; FDA ; Food and Drug Administration ; GALT ; gut associated lymphoid tissue ; GIT ; gastrointestinal tract ; GRAS ; Gene
刊名：European Journal of Pharmaceutics and Biopharmaceutics
出版年：2015
出版时间：November 2015
年：2015
卷：97
期：part_PA
页码：206-217
全文大小：429 K

文摘

•: Gut mucus is a barrier for NPs intended for oral administration of drugs.
•: Nanotoxicology is a crucial field for the nanomedicine development.
•: Nanotoxicology needs standardized protocols to go forward.
•: The physicochemical characteristics of NPs influence their potential toxic effect.
•: Polymeric NPs seem not have acute toxic effects; chronic studies are needed.

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