Suicide is a serious public health problem worldwide with an estimated annual mortality rate of 14.5 deaths per 100,000 people.

FKBP5 and CRHR1 genes have been associated importantly with epigenetic alterations in molecular pathways of the function HPA axis and serotonergic system in patients with suicidal behavior.

An understanding of the functional consequence of FKBP5 and CRHR1 genes and its polymorphisms from a neuropathological perspective would be convenient to advance our understanding of their role in the HPA axis alterations with suicidal behavior.