Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: Experience in a Chinese single institution

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• 作者：Xin Zhao ; Kang Zhou ; Liping Jing ; Li Zhang ; Guangxin Peng ; Yang Li ; Lei Ye ; Jianping Li ; Huihui Fan ; Yuan Li ; Fengkui Zhang ; ^{zhfk@hotmail.com}
• 关键词：T-cell large granular lymphocyte leukemia ; LGL ; Cyclosporine A ; Glucocorticoid ; Cyclophosphamide
• 刊名：Leukemia Research
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：37
• 期：5
• 页码：547-551
• 全文大小：225 K

文摘

T-cell large granular lymphocyte leukemia (T-LGLL) is a rare chronic lymphoproliferative disorder. Available reported data on the treatment regimens of this disease are variable and limited due to low number of patients. We analyzed the efficiency of cyclosporine A (CsA) in the treatment of 28 patients with T-LGLL. The overall response rate (ORR) was 82.1 % with hematologic complete remission (HCR) rate of 57.1 % . The median time to response (TTR) was 1.8 months and treatment duration with CsA-based regimens was 34.5 months. CsA shows low and manageable toxicity during treatment. Twenty-one patients survived with a median follow-up time of 42.0 months. Our results indicate that CsA is efficacious and safe in the treatment of T-LGLL.