Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis

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Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis

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作者：Sandra Hellberg¹ ; ⁸ ; Daniel Eklund¹ ; ⁸ ; ^{daniel.eklund@liu.se" class="auth_mail" title="E-mail the corresponding author} ; Danuta R. Gawel² ; Mattias Kö ; psé ; n² ; ³ ; Huan Zhang² ; Colm E. Nestor² ; Ingrid Kockum⁴ ; Tomas Olsson⁴ ; Thomas Skogh⁵ ; Alf Kastbom⁵ ; Christopher Sjö ; wall⁵ ; Magnus Vrethem⁶ ; Irene Hå ; kansson⁶ ; Mikael Benson² ; Maria C. Jenmalm¹ ; Mika Gustafsson³ ; ⁹ ; ^{mika.gustafsson@liu.se" class="auth_mail" title="E-mail the corresponding author} ; Jan Ernerudh⁷
刊名：Cell Reports
出版年：2016
出版时间：13 September 2016
年：2016
卷：16
期：11
页码：2928-2939
全文大小：2500 K

文摘

•: Dynamic CD4+ T cell responses in vitro revealed a dysregulated network module in MS
•: This module was highly enriched for GWAS genes and translated into protein expression
•: A combined protein score readily predicted disease activity and treatment response
•: Integrating GWASs with dynamic expression profiling disclosed personalized biomarkers

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