Inhibition of endoplasmic reticulum stress by neuregulin-1 protects against myocardial ischemia/reperfusion injury

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• 作者：Shan-Juan Fang^a ; Peng-Yang Li^b ; Chun-Mei Wang^a ; Yi Xin^a ; Wei-Wei Lu^b ; ^c ; Xiao-Xia Zhang^a ; Song Zuo^a ; Chang-Sheng Ma^a ; Chao-Shu Tang^b ; Shao-Ping Nie^a ; ^{spnie@126.com} ; Yong-Fen Qi^b ; ^c ; ^{yongfenqi@163.com}
• 关键词：ER ; endoplasmic reticulum ; Tm ; tunicamycin ; DTT ; dithiothreitol ; CHOP ; CCAAT/enhancer binding protein homologous protein ; I/R ; ischemia/reperfusion ; NRG-1 ; Neuregulin-1 ; CM ; cardiomyocyte ; ERK ; extracellular signal-regulated kinase ; SD ; Sprague-Dawley ; P13K ; Phosphoinositide 3-kinase ; TUNEL ; terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling ; siRNA ; small interfering RNA ; NRVM ; neonatal rat ventricular myocyte ; DMEM ; Dulbecco&rsquo ; s modified Eagle medium ; FBS ; fetal bovine se
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：196-207
• 全文大小：3542 K
• 卷排序：88

文摘

NRG-1 inhibits cardiomyocyte ER stress induced by tunicamycin and dithiothreitol. NRG-1 inhibits cardiomyocyte ER stress through ErbB4 receptor. The inhibitory effects of NRG-1 on cardiomyocyte ER stress is through PI3K/Akt signaling pathway. NRG-1 attenuates apoptosis and ER stress induced by H/R in cardiomyocytes. NRG-1 reduces the myocardial I/R injury and ER stress in I/R heart.