Streptococcus pneumoniae infection regulates expression of neurotrophic factors in the olfactory bulb and cultured olfactory ensheathing cells

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Streptococcus pneumoniae infection regulates expression of neurotrophic factors in the olfactory bulb and cultured olfactory ensheathing cells

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作者：S. Ruiz-Mendoza^a ; ^b ; H. Macedo-Ramos^a ; ^b ; F.A. Santos^a ; L.C. Quadros-de-Souza^a ; M.M. Paiva^c ; T.C.A. Pinto^d ; L.M. Teixeira^d ; W. Baetas-da-Cruz^a ; ^b ; ^{wagner.baetas@ufrj.br" class="auth_mail" title="E-mail the corresponding author}
关键词：BNDF ; Brain-derived neurotrophic factor ; CM-I-OEC ; conditioned medium from infected ; CM-OEC ; conditioned medium from uninfected ; CNTF ; Ciliary neurotrophic factor ; DF ; dermal fibroblast ; GAPDH ; Glyceraldehyde-3-phosphate dehydrogenase ; GDNF ; Glial cell-line-derived neurotrophic factor ; HMGB1 ; High-mobility group box 1 ; NFκB ; nuclear factor-kappa B ; NGF ; Nerve growth factor ; NT-3 ; Neurotrophin-3 ; OECs ; Olfactory ensheathing cells ; ORNs ; olfactory receptor neurons
刊名：Neuroscience
出版年：2016
出版时间：11 March 2016
年：2016
卷：317
期：Complete
页码：149-161
全文大小：3882 K

文摘

•: Neurotrophic factors’ expression was significantly lower in the olfactory bulb from infected mice.
•: In vitro infection of OECs resulted in a significant increase of BDNF mRNA expression.
•: HMGB1 expression was increased in both olfactory bulb and OEC cultures infected with S. pneumoniae.
•: Conditioned medium of OEC/S. pneumoniae induced cleaved caspase-3 expression and NF-κB activation in N13 microglia.

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