Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome

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• 作者：Syam S. Andra ; ^{syam.andra@mssm.edu} ; Christine Austin ; Dhavalkumar Patel ; Georgia Dolios ; Mahmoud Awawda ; Manish Arora ; ^{manish.arora@mssm.edu}
• 刊名：Environment International
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：32-61
• 全文大小：1167 K
• 卷排序：100

文摘

Human biomonitoring is limited by the number of chemicals analyzed in a targeted approach. High resolution mass spectrometry (HRMS) can monitor a broad-spectrum of exposure and biological response markers. Advances in data acquisition workflows accelerate untargeted profiling of the human exposome environmental chemical space. Intelligent data mining filters and tools are constantly evolving to characterize unknown compounds. High throughput simultaneous identification and quantitation of new chemicals and metabolites will be feasible with HRMS.