Decreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment

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• 作者：Elyse MacFadden-Murphy ; Lucie Roussel ; Guy Martel ; Julie Bé ; rubé ; Simon Rousseau ; ^{simon.rousseau@mcgill.ca}
• 关键词：Niemann-Pick disease ; Acidic sphingomyelinase ; Airway epithelium ; Interleukins ; Pseudomonas aeruginosa ; Reactive oxygen species
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：645-650
• 全文大小：742 K
• 卷排序：482

文摘

Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them. Decreasing SMPD1 activity in epithelial cells leads to higher cytokine secretion. Decreasing SMPD1 activity results in a pro-oxidative shift of epithelial cells. An inactive SMPD1 mutant activates NRF2 in airway epithelial cells.