Disruption of motor behavior and injury to the CNS induced by 3-thienylboronic acid in mice

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Disruption of motor behavior and injury to the CNS induced by 3-thienylboronic acid in mice

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作者：E.D. Farfá ; n-Garcí ; a^a ; M. Pé ; rez-Rodrí ; guez^a ; C. Espinosa-Garcí ; a^b ; N.T. Castillo-Mendieta^a ; M. Maldonado-Castro^a ; E. Querejeta^a ; J.G. Trujillo-Ferrara^a ; M.A. Soriano-Ursú ; a^a ; ^{msoriano@ipn.mx" class="auth_mail" title="E-mail the corresponding author}
关键词：Boron ; Movement disorders ; Basal ganglia ; Cerebellum ; Boron-containing compounds ; Raman spectroscopy
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 September 2016
年：2016
卷：307
期：Complete
页码：130-137
全文大小：737 K

文摘

•: Intraperitoneal 3-thienylboronic acid (3TB) induces tremor in CD1 or C57BL6 mice.
•: Injury on CNS as well as motor disruption is dose-dependent.
•: Damage is greater in basal ganglia than in cerebellum or motor cortex.
•: The DMSO as vehicle plays a key role in the induced effect.
•: Motor disruption seems to involve basal ganglia and cerebellum damage.

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