Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders

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Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders

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作者：Benjamin Lemaire^a ; ¹ ; ² ; Akira Kubota^a ; ³ ; Conor M. O'Meara^a ; David C. Lamb^b ; Robert L. Tanguay^c ; Jared V. Goldstone^a ; John J. Stegeman^a ; ² ; ^{jstegeman@whoi.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：AHR ; aryl hydrocarbon receptor ; AR ; androgen receptor ; arnt2 ; aryl hydrocarbon receptor nuclear translocator 2 ; CYP ; cytochrome P450 ; DES ; diethylstilbestrol ; dpf ; days post-fertilization ; ef1α ; elongation factor 1 alpha ; ER ; estrogen receptor ; ERR ; estrogen-related receptor ; FXR ; farnesoid X receptor ; GR ; glucocorticoid receptor ; HNF4 ; hepatocyte nuclear factor 4 ; hpf ; hours post-fertilization ; LXR ; liver X receptor ; MeHg ; methylmercury ; MO ; morpholino ; OMR ; optomotor response ; PCB ; polychlorin
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：1 April 2016
年：2016
卷：296
期：Complete
页码：73-84
全文大小：1063 K

文摘

•: The “orphan” CYP20A1 was cloned from zebrafish and its sequence analyzed.
•: Knockdown of CYP20A1 reduced an optomotor response and elicited bursts of activity.
•: Effects of knockdown resemble some features of a microdeletion of CYP20A1 in human.
•: Expression of CYP20A1 was downregulated by the neurotoxicant methylmercury.
•: CYP20A1 may be involved in neurobehavioral processes and effects of some chemicals.

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