Participation of protein kinases in cytotoxic and proapoptotic effects of ethylene glycol ethers and their metabolites in SH-SY5Y cells

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Participation of protein kinases in cytotoxic and proapoptotic effects of ethylene glycol ethers and their metabolites in SH-SY5Y cells

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作者：Bartosz Pomierny ; Ph.D.^a ; ^b ; ^{bartosz.pomierny@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Kjell Fuxe ; Prof.^b ; ^{Kjell.Fuxe@ki.se" class="auth_mail" title="E-mail the corresponding author} ; Weronika Krzyżanowska ; M.Sc.^a ; ^{weronika.krzyzanowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Magdalena Regulska ; Ph.D.^c ; ^{regulska@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author} ; Żaneta Broniowska ; M.Sc.^a ; ^{zaneta.broniowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Bogusława Budziszewska ; Prof.^a ; ^c ; ^{boguslawa.budziszewska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author}
关键词：EGEs ; ethylene glycol ethers ; BE ; 2-butoxyethanol ; BA ; butoxyacetic acid ; EE ; 2-ethoxyethanol ; EA ; ethoxyacetic acid ; PHE ; 2-phenoxyethanol ; PHA ; phenoxyacetic acid
刊名：Toxicology in Vitro
出版年：2016
出版时间：October 2016
年：2016
卷：36
期：Complete
页码：153-163
全文大小：1342 K

文摘

•: EGEs and their metabolites exhibit severe cytotoxic properties on neuroblastoma cells.
•: EGEs and their metabolites, affecting different protein kinases, stimulate apoptosis.
•: EGEs may be involved in the initiation of neurodegeneration process.
•: 20">EGEs and their metabolites significantly increase reactive oxygen species (ROS) production.

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