Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata

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Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata

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作者：Elias Baydoun^a ; ^{eliasbay@aub.edu.lb" class="auth_mail" title="E-mail the corresponding author} ; Atia-tul Wahab^b ; Nayab Shoaib^c ; Malik Shoaib Ahmad^c ; Roula Abdel-Massih^d ; Colin Smith^a ; Nimra Naveed^c ; M. Iqbal Choudhary^b ; ^c ; ^e ; ^{iqbal.choudhary@iccs.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Etonogestrel ; Contraceptive ; Biotransformation ; Cunninghamella blakesleeana ; Cunninghamella echinulata ; β-Glucuronidase inhibition ; Colon cancer
刊名：Steroids
出版年：2016
出版时间：November 2016
年：2016
卷：115
期：Complete
页码：56-61
全文大小：504 K

文摘

•: Five metabolites of contraceptive drug etonogestrel (1) were synthesized through biotransformation by fungi.
•: Biotransformation of 1Cunninghamella blakesleeana yielded metabolites 2–6.
•: Biotransformation of 1Cunninghamella echinulata yielded metabolites 2, 4, and 6.
•: 6β-Hydroxy-etonogestrel (5) was found to be active against β-glucuronidase enzyme.

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