Parathyroidectomy for primary hyperparathyroidism improves sleep quality: A prospective study

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• 作者：Justin La ; BS^a ; Tracy S. Wang ; MD ; MPH^a ; Abdulrahman Y. Hammad ; MD^a ; Laura Burgardt ; BS^a ; Kara Doffek ; BS^a ; Azadeh A. Carr ; MD^a ; Joseph L. Shaker ; MD^b ; Ty B. Carroll ; MD^b ; Douglas B. Evans ; MD^a ; Tina W.F. Yen ; MD ; MS^a ; ^tyen@mcw.edu
• 刊名：Surgery
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：161
• 期：1
• 页码：25-34
• 全文大小：610 K
• 卷排序：161

文摘

This prospective survey study assessed changes in sleep quality in patients with primary hyperparathyroidism after parathyroidectomy.MethodsPatients undergoing parathyroidectomy for primary hyperparathyroidism (n = 110) or thyroidectomy for benign euthyroid disease (control group; n = 45) were recruited between June 2013 and June 2015 and completed the Pittsburgh Sleep Quality Index preoperatively and at 1- and 6 months postoperatively. “Poor” sleep quality was defined as a score >5; a clinically important and relevant improvement was a ≥3-point decrease.ResultsPreoperatively, parathyroid patients had worse sleep quality than thyroid patients (mean 8.1 vs 5.3; P < .001); 76 (69%) parathyroid and 23 (51%) thyroid patients reported poor sleep quality (P = .03). Postoperatively, only parathyroid patients demonstrated improvement in sleep quality; mean scores did not differ between the parathyroid and thyroid groups at 1 month (6.3 vs 5.3; P = .12) or 6 months (5.8 vs 4.6; P = .11). The proportion of patients with a clinically important improvement in sleep quality was greater in the parathyroid group at 1 month (37% vs 10%; P < .001) and 6 months (40% vs 17%; P = .01). Importantly, there was no difference in the proportion of patients with poor sleep quality between the 2 groups at 1 month (50% vs 40%; P = .32) and 6 months (40% vs 29%; P = .22).ConclusionMore than two-thirds of patients with primary hyperparathyroidism report poor sleep quality. After parathyroidectomy, over one-third experienced improvement, typically within the first month postoperatively.