Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP<sup>+</sup>-linked-polyhydroxybenzoates

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Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP⁺-linked-polyhydroxybenzoates

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作者：Cristian Sandoval-Acuñ ; a^a ; ^b ; Sebastiá ; n Fuentes-Retamal^a ; Daniela Guzmá ; n-Rivera^a ; Liliana Peredo-Silva^a ; Matí ; as Madrid-Rojas^c ; Solange Rebolledo^c ; Vicente Castro-Castillo^d ; Mario Pavani^a ; Mabel Catalá ; n^a ; Juan Diego Maya^a ; José ; A. Jara^e ; Eduardo Parra^f ; Gloria M. Calaf^g ; Herná ; n Speisky^b ; Jorge Ferreira^a ; ^{jferreir@med.uchile.cl" class="auth_mail" title="E-mail the corresponding author}
关键词：AMPK ; AMP-activated protein kinase ; Ap5A ; P1 ; P5-di(adenosine-5&prime ; )pentaphosphate ; AV ; annexin V ; BC ; breast cancer ; BrdU ; bromodeoxyuridine ; CCCP ; carbonyl cyanide m-chlorophenyl hydrazine ; CSC ; cancer stem cells ; ER ; estrogen receptor ; ETC ; electron transport chain ; HER2/neu ; human epidermal growth factor receptor-2 ; LDH ; lactate dehydrogenase ; mtDNA ; mitochondrial DNA ; P(Ph)3 ; triphenylphosphine ; PI ; propidium iodide ; PR ; progesterone receptor ; RFU ; relative fluorescence units ; ROS ; reacti
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 October 2016
年：2016
卷：309
期：Complete
页码：2-14
全文大小：1813 K

文摘

•: TPP⁺-polyhydroxybenzoates are cytotoxic to various subtypes of breast cancer cells.
•: Cytotoxicity is not-dependent on the expression of estrogen/growth factor receptors.
•: Cytotoxicity appears to be triggered by a weak mitochondrial uncoupling effect.
•: Effects include loss of transmembrane potential and apoptosis was detected.
•: TPP⁺-polyhydroxybenzoates inhibit migration of highly metastatic cells.

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