Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation

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Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation

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作者：Erica A. Dale^a ; ¹ ; ² ; Daryl P. Fields^a ; ^b ; ¹ ; Michael J. Devinney^a ; Gordon S. Mitchell^a ; ^b ; ^{gsmitche@phhp.ufl.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：5HT ; serotonin ; AIH ; acute intermittent hypoxia ; BDNF ; brain derived neurotrophic factor ; CtB ; choleratoxin B fragment ; ERK ; extracellular regulated kinase ; LTP ; long term potentiation ; Nx ; normoxia ; (p)LTF ; (phrenic) long-term facilitation ; siNT ; non-targeting siRNA ; siTrkB ; siRNA targeting TrkB ; TrkB ; tropomyosin related kinase B
刊名：Experimental Neurology
出版年：2017
出版时间：January 2017
年：2017
卷：287
期：part_P2
页码：130-136
全文大小：851 K

文摘

•: Acute intermittent hypoxia-induced respiratory motor plasticity requires BDNF signaling.
•: Phrenic motor neurons express the high affinity BDNF receptor TrkB.
•: Intrapleural siRNA targeting TrkB receptors decreased TrkB receptor expression selectively on phrenic motor neurons.
•: Intrapleural siRNA targeting TrkB receptors abolished BDNF dependent, hypoxia-induced respiratory motor plasticity.
•: Phrenic motor neurons are a critical site for spinal respiratory motor plasticity.

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