Age-related alterations in the genetics and genomics of the male germ line

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• 作者：Amin S. Herati ; M.D.^a ; ^b ; Boryana H. Zhelyazkova ; B.A.^c ; Peter R. Butler ; B.A.^a ; ^b ; Dolores J. Lamb ; Ph.D.^a ; ^b ; ^c ; ^{dlamb@bcm.edu}
• 关键词：Genetics ; humans ; male ; paternal age ; reproduction
• 刊名：Fertility and Sterility
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：107
• 期：2
• 页码：319-323
• 全文大小：323 K
• 卷排序：107

文摘

Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.