Practical one-pot sequential procedure for the preparation of N

详细信息    查看全文

• 作者：Rui Zhu ; Lixin Xing ; Yantao Liu ; Fangkun Deng ; Xinyan Wang ; Yuefei Hu
• 关键词：Alkenes ; Arylations ; Copper ; Coupling ; Pyrroles
• 刊名：Journal of Organometallic Chemistry
• 出版年：2008
• 出版时间：15 December 2008
• 年：2008
• 卷：693
• 期：26
• 页码：3897-3901
• 全文大小：186 K

文摘

By using ^tBuONa and Cs₂CO₃ as a mixed base, van Leusen pyrrole synthesis and copper-catalyzed N-arylation of pyrrole proceeded sequentially in a single flask to give N-arylated 3,4-disubstituted pyrroles smoothly. Thus, a series of desired N-arylated pyrroles were prepared directly from the electron-deficient alkenes.