Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

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• 作者：Yannick Simoni¹ ; ^{yannick_simoni@immunol.a-star.edu.sg} ; Michael Fehlings¹ ; Henrik N. Klø ; verpris² ; ³ ; Naomi McGovern¹ ; Si-Lin Koo⁴ ; Chiew Yee Loh¹ ; Shawn Lim¹ ; Ayako Kurioka⁵ ; Joannah R. Fergusson⁵ ; Choong-Leong Tang⁶ ; Ming Hian Kam⁶ ; Koh Dennis⁶ ; ⁷ ; Tony Kiat Hon Lim⁸ ; Alexander Chung Yaw Fui⁹ ; Chan Weng Hoong¹⁰ ; Jerry Kok Yen Chan¹¹ ; ¹² ; Maria Curotto de Lafaille¹ ; ¹⁵ ; Sriram Narayanan¹³ ; Sonia Baig¹⁴ ; Muhammad Shabeer¹⁴ ; Sue-Anne Ee Shiow Toh¹² ; ¹⁴ ; ¹⁶ ; ¹⁷ ; Henry Kun Kiaang Tan¹⁸ ; Rosslyn Anicete¹⁸ ; Eng-Huat Tan⁴ ; Angela Takano⁸ ; Paul Klenerman⁵ ; Alasdair Leslie² ; Daniel S.W. Tan⁴ ; ¹⁹ ; Iain Beehuat Tan⁴ ; ¹² ; ¹⁹ ; Florent Ginhoux¹ ; Evan W. Newell¹ ; ²⁰ ; ^{evan_newell@immunol.a-star.edu.sg}
• 关键词：ILC ; ILC1 ; ieILC1 ; ILC2 ; ILC3 ; human ; CyTOF
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：148-161
• 全文大小：6355 K
• 卷排序：46

文摘

Comprehensive profiling of human ILCs across tissues Detailed description of previously defined ILC subsets except helper-type ILC1 ieILC1-like cells are present in several tissues and functionally similar to NK cells Identification of markers expressed on ILCs, including functional IL-18R