Evidence of sexual dimorphism in placental vitamin D metabolism: Testosterone inhibits calcitriol-dependent cathelicidin expression

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Evidence of sexual dimorphism in placental vitamin D metabolism: Testosterone inhibits calcitriol-dependent cathelicidin expression

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作者：Andrea Olmos-Ortiz^a ; ^g ; Janice Garcí ; a-Quiroz^a ; Rebeca Ló ; pez-Marure^b ; Irma Gonzá ; lez-Curiel^c ; Bruno Rivas-Santiago^d ; Aleida Olivares^e ; Euclides Avila^a ; David Barrera^a ; Ali Halhali^a ; Felipe Caldi&ntilde ; o^f ; Fernando Larrea^a ; Lorenza Dí ; az^a ; ^{lorenzadiaz@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：25OHD3 ; 25-hydroxyvitamin D3 ; AR ; Androgen Receptor ; cAMP ; cyclic AMP ; CRE ; cAMP response elements ; CREB ; cAMP response element binding protein ; DHT ; 5α-dihydrotestosterone ; E2 ; 17β-estradiol ; hCTD ; human Cathelicidin ; VD ; vitamin D ; VDR ; vitamin D receptor
刊名：Journal of Steroid Biochemistry and Molecular Biology
出版年：2016
出版时间：October 2016
年：2016
卷：163
期：Complete
页码：173-182
全文大小：1397 K

文摘

•: Testosterone stimulates CYP24A1and inhibits CYP27B1 placental gene expression.
•: Testosterone phosphorylates CREB in a cAMP independent and AR dependent manner.
•: The placental VD-dependent expression of hCTD is reduced by androgen exposure.
•: Male placental cotyledons express less CYP27B1 and hCTD mRNA compared to females.
•: Male newborns had lower serum umbilical cord hCTD concentration compared to females.

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