Methionine enkephalin regulates microglia polarization and function

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Methionine enkephalin regulates microglia polarization and function

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作者：Xuxu Xu^a ; Yan Gao^a ; Lulu Wen^a ; Zhiyong Zhai^a ; Shuo Zhang^a ; Fengping Shan^b ; Juan Feng^a ; ^{cmufengjuan@sina.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Arg1 ; arginase-1 ; CNS ; central nervous system ; CAMK ; Ca2 ; +/calcineurin-dependent protein kinase ; DCs ; dendritic cells ; DMEM ; Dulbecco's modified Eagle medium ; ELISA ; enzyme-linked immunosorbent assay ; FCM ; flow cytometry ; IFN-γ ; interferon-γ ; iNOS ; inducible NO synthase ; LPS ; lipopolysaccharide ; MENK ; methionine enkephalin ; NO ; nitric oxide ; OD ; optical density ; ROS ; reactive oxygen&ndash ; nitrogen species ; TLR ; toll-like receptor
刊名：International Immunopharmacology
出版年：2016
出版时间：November 2016
年：2016
卷：40
期：Complete
页码：90-97
全文大小：735 K

文摘

•: MENK therapy induced up-regulation of CD86, CD40, IL-12, and TNF-α, but had no effect on CD163, IL-10, and TGF-β.
•: A high phagocytosis capacity and increased expression of ROS, nitrite and iNOS were observed in MENK-treated microglia.
•: Supernatants from MENK-treated microglia induced cytotoxicity against glioblastoma cells.

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