SNF2H interacts with XRCC1 and is involved in repair of H<sub>2</sub>O<sub>2</sub>-induced DNA damage

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SNF2H interacts with XRCC1 and is involved in repair of H₂O₂-induced DNA damage

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作者：Yoshiko Kubota^a ; ^{yoshikok@iwate-med.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shinji Shimizu^a ; Shinji Yasuhira^b ; Saburo Horiuchi^a
关键词：AP sites ; apurinic/apyrimidinic sites ; BER ; base excision repair ; CBB ; Coomassie Brilliant Blue ; CK2 ; ; casein kinase 2 ; DSB ; double-strand break ; OGG1 ; 8-oxoguanine DNA glycosylase ; PAR ; poly(ADP-ribose) ; PARP ; poly(ADP-ribose) polymerase ; SNF2H ; sucrose non-fermenting protein 2 homolog ; XRCC1 ; X-ray repair cross-complementing protein 1
刊名：DNA Repair
出版年：2016
出版时间：July 2016
年：2016
卷：43
期：Complete
页码：69-77
全文大小：2051 K

文摘

•: CK2-dependent phosphorylation of XRCC1 is crucial for its interaction with SNF2H.
•: Foci-formation of XRCC1 and PAR in response to H₂O₂ treatment is dependent on SNF2H.
•: Knock-down of SNF2H impede repair of H₂O₂-induced lesion.

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