Isolation and expansion of human adenovirus–specific CD4⁺ and CD8⁺ T cells according to IFN-γ secretion for adjuvant immunotherapy

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• 作者：Feuchtinger ; Tobias ; Lang ; Peter ; Hamprecht ; Klaus ; Schumm ; Michael ; Greil ; Johann ; Jahn ; Gerhard ; et. al.
• 刊名：Experimental Hematology
• 出版年：2004
• 出版时间：March, 2004
• 年：2004
• 卷：32
• 期：3
• 页码：282-289
• 全文大小：289 K

文摘

In patients with lymphopenia following allogeneic stem cell transplantation adenovirus (ADV) infection is associated with high morbidity and mortality despite aggressive antiviral drug therapy. Virus-specific T cells seem to be essential for virus elimination. The aim of this study was to isolate and expand donor-derived human ADV-specific T lymphocytes for adoptive transfer of sufficient cell numbers to restore protective immunity after allogeneic stem cell transplantation.