Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system

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• 作者：A. Dash^a ; ¹ ; R.A. Figler^a ; ¹ ; B.R. Blackman^b ; S. Marukian^a ; M.S. Collado^a ; M.J. Lawson^a ; S.A. Hoang^a ; A.J. Mackey^a ; D. Manka^a ; B.K. Cole^a ; R.E. Feaver^a ; A.J. Sanyal^c ; B.R. Wamhoff^a ; ^{Wamhoff@HemoShear.com}
• 关键词：NASH ; nonalcoholic steatohepatitis ; NAFD ; nonalcoholic fatty liver disease ; FXR ; farnesoid X receptor ; FGF19 ; fibroblast growth factor ; DMSO ; dimethyl sulfoxide ; CYP ; cytochrome P450
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：93-103
• 全文大小：1858 K
• 卷排序：39

文摘

Clinical concentrations of obeticholic acid were tested in an organotypic liver model. Transcriptomics reveal metabolic pathway effects beneficial in fatty liver disease. Changes predictive of lipoprotein abnormalities were also noted. Cytochrome P450 effects raise concern for potential drug-drug interactions.