Integrated and comparative miRNA analysis of starvation-induced autophagy in mouse embryonic fibroblasts

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Integrated and comparative miRNA analysis of starvation-induced autophagy in mouse embryonic fibroblasts

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作者：Jianzhou Cui^a ; ^{jianzhou_cui@nuhs.edu.sg" class="auth_mail" title="E-mail the corresponding author} ; Kaihui Lu^a ; Yin Shi^a ; Bo Chen^a ; Shi-Hao Tan^a ; ^b ; Zhiyuan Gong^c ; Han-Ming Shen^a ; ^b ; ^{han-ming_shen@nuhs.edu.sg" class="auth_mail" title="E-mail the corresponding author}
关键词：AMPK ; AMP-activated protein kinase ; ATG ; AuTophaGy related ; CQ ; chloroquine ; EBSS ; Earle's balanced salt solution ; FBS ; fetal bovine serum ; FIP200 ; focal adhesion kinase (FAK) family interacting protein of 200 ; kDa ; LC3 ; microtubule-associated protein 1 light chain 3 ; the mammalian homolog of yeast Atg8 ; MAPK ; mitogen-activated protein kinase ; MEF ; mouse embryonic fibroblast ; miRNA ; microRNA ; mTOR ; mammalian target of rapamycin ; PE ; phosphatidylethanolamine ; PI3K ; phosphatidylinositol 3-kina
刊名：Gene
出版年：2015
出版时间：25 October 2015
年：2015
卷：571
期：2
页码：194-204
全文大小：2440 K

文摘

•: miRNAs were significantly altered in Atg5 MEFs in starvation-induced autophagy.
•: miRNAs were mapped to key signaling pathways and Atgs involved in the autophagy.
•: miR-93 negatively regulates cellular autophagic activity.

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