Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2016
出版时间:February 2016
年:2016
卷:1862
期:2
页码:233-239
全文大小:612 K
文摘
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Hydroxyproline metabolism in mice contributes significantly to oxalate synthesis.
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The contribution is greater in Agxt and Grhpr KO mice than in wild type mice.
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Decreasing hepatic GO and HYPDH expression decreases oxalate excretion.
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RNAi therapeutics could be helpful in treating Primary Hyperoxaluria.
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