Epigenetic dysfunctional diseases and therapy for infection and inflammation

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• 作者：Saheli Samanta^a ; Sheeja Rajasingh^a ; Thuy Cao^a ; Buddhadeb Dawn^a ; Johnson Rajasingh^a ; ^b ; ^{rjohnson9@kumc.edu}
• 关键词：Aza ; 5-aza 2 deoxycytidine ; TSA ; trichostatin A ; MeCP2 ; methyl CpG binding protein 2 ; SLE ; systemic lupus erythematosus ; RA ; rheumatoid arthritis ; DNMTs ; DNA methyltransferases ; HDACs ; histone deacetylases ; HAT ; histones acetyl transferases ; HMT ; histone methyl transferases ; HDM ; histone demethylases ; MLH1 ; MutL homologue 1 ; CBP ; CREB-binding protein ; RASF ; rheumatoid arthritis synovial fibroblasts ; PBA ; phenyl butyric acid ; FOXO3 ; forkhead box O3 ; IRF1 ; interferon regulatory factor 1 ; STAT ; sig
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：518-528
• 全文大小：1030 K
• 卷排序：1863

文摘

Epigenetic state plays an important role in disease manifestation. DNA methylation, histone modification, nucleosomal positioning and miRNA, mediate major epigenetic regulation. Environmental factors are also responsible for associate alteration of the epigenetic state. Targeting the epigenetic machinery is a newer approach to change the altered epigenetic state.