Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

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• 作者：David Porras^a ; ^{dporrs00@estudiantes.unileon.es} ; Esther Nistal^a ; ^{esthernistal@hotmail.com} ; Susana Martí ; nez-Fló ; rez^a ; ^{smarf@unileon.es} ; Sandra Pisonero-Vaquero^a ; ^{spisv@unileon.es} ; José ; Luis Olcoz^b ; ^c ; ^{jolcozg@gmail.com} ; Ramiro Jover^b ; ^d ; ^e ; ^{ramiro.jover@uv.es} ; Javier Gonzá ; lez-Gallego^a ; ^b ; ^{jgonga@unileon.es} ; Marí ; a Victoria Garcí ; a-Mediavilla^a ; ^b ; ¹ ; ^{mvgarm@unileon.es} ; Sonia Sá ; nchez-Campos^a ; ^b ; ¹ ; ^{ssanc@unileon.es}
• 关键词：ALT ; alanine aminotransferase ; C/EBPα ; CCAAT/enhancer binding protein alpha ; CHOP ; CCAAT-enhancer-binding protein homologous protein ; CYP2E1 ; cytochrome P450 2E1 ; DAMPs ; danger-associated molecular patterns ; FABP1 ; fatty acid binding protein 1 ; FAS ; fatty acid synthase ; FAT/CD36 ; fatty acid translocase CD36 ; FFA ; free fatty acid ; FOXA1 ; forkhead box protein A1 ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GRP78 ; 78  ; kDa glucose-regulated protein ; HFD ; high fat diet ; HOMA-IR ; homeostasis
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：188-202
• 全文大小：1701 K
• 卷排序：102

文摘

Dysbiosis is accompanied by gut-liver axis alteration in HFD-induced NAFLD. Quercetin prevents dysbiosis-induced TLR4-mediated inflammation and lipotoxicity. Quercetin counteracts inflammasome and reticulum stress pathway activation. Modulatory effects displayed by quercetin counteract lipid metabolism deregulation. Quercetin improves NAFLD via an integrative response including its prebiotic effect.