NOD2 mediates isoflurane preconditioning-induced protection of myocardial injury

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• 作者：Cheng Yang^a ; ¹ ; Yang Jiao^b ; ¹ ; Nuo Yan^a ; Banglin Wu^c ; Yiqing Ren^a ; Hui Li^a ; Jinchao Sun^a ; Jie Gao^a ; ^{jiegaojg@163.com}
• 关键词：A/R ; anoxia/reoxygenation ; NOD2 ; nucleotide binding oligomerization domain containing 2 ; p38MAPK ; p38-mitogen-activated protein kinase ; NLRs ; NOD-like receptors ; GFP ; green fluorescent protein ; FOXO1 ; forkhead box O1 ; NLRP3 ; NLR family pyrin domain containing 3
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：637
• 期：Complete
• 页码：154-160
• 全文大小：1574 K
• 卷排序：637

文摘

Isoflurane ameliorates myocardial injury in primary cardiomyocytes. Isoflurane treatment reduces autophagosome accumulation. Isoflurane increased NOD2 expression in cardiomyocyte cells. Inhibition of NOD2 abrogates the cardioprotection effect caused by isoflurane. NOD2 promotes p38MAPK activation.