The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line

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• 作者：Jian Zhang ; Mahua Choudhury ; ^{mchoudhury@pharmacy.tamhsc.edu} ;
• 关键词：BBP ; Benzyl butyl phthalate ; PGC1α ; Peroxisome proliferator-activated receptor gamma coactivator 1 alpha ; NRF1 ; Nuclear respiratory factor 1 ; NRF2 ; Nuclear respiratory factor 2 ; Tfam ; Mitochondrial transcription factor A ; FOXO1 ; Forkhead box protein O1
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：75-83
• 全文大小：1782 K
• 卷排序：39

文摘

BBP increased adipogenesis in mesenchymal stem cells. BBP selectively decreased sirtuin gene or protein expression during adipogenesis. BBP also decreased the mitochondrial biogenesis regulator gene expression. BBP increased overall protein acetylation levels. BBP increased acetylation of FOXO1 and β-catenin in mesenchymal stem cell.