Zinc-mediated synthesis of 3-alkynyl-3-hydroxyindolin-2-ones by addition of iodoalkynes to isatins

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• 作者：Vinay K. Singh ; Abhishek Upadhyay ; Rana Krishna Pal Singh ; ^{rkp.singh@rediffmail.com}
• 关键词：Two component reaction ; CC bond formation ; Isatin ; Nucleophilic addition reaction ; Zinc mediated
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：58
• 期：2
• 页码：156-158
• 全文大小：634 K
• 卷排序：58

文摘

CC bond formation reaction is a very important transformation in organic chemistry. 3-Substituted 3-hydroxyl-2-oxindole showing tremendous biological activity. Zinc dust is stable at low temperature, high temperature and room temperature. Zinc has high tolerance of air and moisture easy to handle in the reaction. Clean reaction conditions and an easy workup procedure make this an attractive protocol.