Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

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• 作者：Alice Arcourt¹ ; Louise Gorham¹ ; Rahul Dhandapani² ; Vincenzo Prato¹ ; Francisco J. Taberner¹ ; Hagen Wende¹ ; ³ ; Vijayan Gangadharan¹ ; Carmen Birchmeier³ ; Paul A. Heppenstall² ; Stefan G. Lechner¹ ; ⁴ ; ^{stefan.lechner@pharma.uni-heidelberg.de}
• 关键词：pinprick pain ; acute pain ; nociceptor ; gate control theory ; Npy2r ; MafA ; A-fiber mechanonociceptors ; optogenetics ; primary afferent ; dorsal root ganglion
• 刊名：Neuron
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：93
• 期：1
• 页码：179-193
• 全文大小：6756 K
• 卷排序：93

文摘

Identification of an A-fiber nociceptor subpopulation that mediates pinprick pain Tactile sensory input alleviates A-fiber nociceptor-evoked pain Tactile sensory input is required for nociceptive reflex coordination Pinprick-evoked paw withdrawal reflex is triggered independently of firing frequency