New antifouling macrodiolides from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021

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• 作者：Yu-Lin Sun^b ; Xiao-Yong Zhang^a ; Xu-Hua Nong^a ; Xin-Ya Xu^a ; Shu-Hua Qi^a ; ^{shuhuaqi@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Deep-sea-derived fungus ; Trichobotrys effuse ; Macrodiolide ; Trichobotrysides A&ndash ; C ; Absolute configuration ; Antifouling
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：20 January 2016
• 年：2016
• 卷：57
• 期：3
• 页码：366-370
• 全文大小：619 K

文摘

A new symmetric 16-membered macrodiolide, trichobotryside A (1), and two new asymmetric 18-membered macrodiolides trichobotrysides B–C (2–3) were obtained from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by the methanolysis and modified Mosher method. And the methanolysis of both 1 and 2 produced the new compound of 4R,7S,9S-trihydroxyl-2-en-1-methyl decanoate (4). It was rare to obtain an 18-membered macrodiolide from nature. Compound 1 showed strong antifouling activity against Bugula neritina and Balanus amphitrite larvae settlement.