Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3

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Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3

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作者：Luting Yang¹ ; Bing Li¹ ; Erle Dang ; Liang Jin ; Xueli Fan ; Gang Wang ; ^{xjwgang@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Psoriasis ; Regulatory T cells ; STAT3 ; Pro-inflammatory cytokines
刊名：Journal of Dermatological Science
出版年：2016
出版时间：February 2016
年：2016
卷：81
期：2
页码：85-92
全文大小：1748 K

文摘

•: Tregs from psoriatic patients showed poorly activity in their suppressive and proliferative functions.
•: Phospho-STAT3 was up-regulated in the peripheral blood of psoriatic Tregs.
•: Inhibitor of STAT3 pathway partially restored suppressive function of psoriatic Tregs and restrained the high release of pro-inflammatory cytokines.
•: IL-6, IL-21 and IL-23 induced STAT3 phosphorylation in Tregs.

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