The expression pattern and inhibitory influence of Tenascin-C on the growth of spiral ganglion neurons suggest a regulatory role as boundary formation molecule in the postnatal mouse inner ear

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The expression pattern and inhibitory influence of Tenascin-C on the growth of spiral ganglion neurons suggest a regulatory role as boundary formation molecule in the postnatal mouse inner ear

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作者：M. Kwiatkowska^a ; ^&dagger ; ; J. Reinhard^b ; ^&dagger ; ; L. Roll^b ; N. Kraft^a ; S. Dazert^a ; A. Faissner^b ; S. Volkenstein^a ; ^{Stefan.Volkenstein@rub.de" class="auth_mail" title="E-mail the corresponding author}
关键词：BDNF ; brain-derived neurotrophic factor ; BM ; basilar membrane ; BSA ; bovine serum albumin ; CI ; cochlear implant ; CSPG ; chondroitin sulfate proteoglycan ; DAPI ; 4 ; 6-diamidino-2-phenylindole ; DC ; Deiter&rsquo ; s cell ; DSD-1-PG ; dermatan sulfate-dependent proteoglycan-1 ; ECM ; extracellular matrix ; EDTA ; ethylenediaminetetraacetic acid ; FN ; fibronectin ; HC ; hair cell ; LN ; laminin ; MABT ; maleic acid buffer containing Tween-20 ; MC ; mesothelial cell ; NF-200 ; neurofilament-200 ; NT-3 ; neurotrophin-3 ; OC ; or
刊名：Neuroscience
出版年：2016
出版时间：5 April 2016
年：2016
卷：319
期：Complete
页码：46-58
全文大小：3591 K

文摘

•: Tenascin-C is expressed in the organ of Corti and synaptic regions of the postnatal mouse cochlea.
•: Tenascin-C and Fibronectin are anti-adhesive substrates for spiral ganglion neurons.
•: The DSD-1 epitope is expressed at hair cell stereocilia and spiral ganglion neurites.
•: Tenascin-C may act as an important boundary formation molecule during neuritogenesis in the cochlea.
•: Tenascin-C is a promising candidate to regulate neurite growth in cochlear implants.