Chlorisondamine, a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge

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Chlorisondamine, a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge

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作者：Michael J. Pecaut^a ; ^b ; ^c ; ^{mpecaut@llu.edu" class="auth_mail" title="E-mail the corresponding author} ; Shalini Mehrotra^a ; Xian Luo-Owen^d ; Erben J.M. Bayeta^a ; Denise L. Bellinger^e ; Daila S. Gridley^a ; ^b ; ^c
关键词：Whole-body irradiation ; Protons ; Chlorisondamine ; Sympathetic nervous system ; Cytokines
刊名：Immunology Letters
出版年：2015
出版时间：October 2015
年：2015
卷：167
期：2
页码：103-115
全文大小：2350 K

文摘

•: Radiation augments bacteria-induced increases in cytokines.
•: Sympathetic blockade reduced radiation-induced inflammation.
•: Radiation-induced decrements in host defense mediated by sympathetics.

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