Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer

详细信息查看全文

作者：Balney Rajitha^a ; ^b ; Astrid Belalcazar^a ; Ganji Purnachandra Nagaraju^a ; ^c ; Walid L. Shaib^a ; James P. Snyder^d ; Mamoru Shoji^a ; Subasini Pattnaik^c ; Afroz Alam^b ; Bassel F. El-Rayes^a ; ^{belraye@emory.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Curcumin ; EF31 ; UBS109 ; colorectal cancer ; nuclear factor kappa B
刊名：Cancer Letters
出版年：2016
出版时间：10 April 2016
年：2016
卷：373
期：2
页码：227-233
全文大小：2146 K

文摘

•: UBS109 and EF31 are more potent inhibitors of cell cycle progression than curcumin.
•: UBS109 and EF31 inhibit NF-κB and TS leading to decreased DNA synthesis.
•: UBS109 and EF31 and curcumin induce expression of silenced p16 and p21.
•: UBS109 and EF31 are promising analogues for future therapeutic development in CRC.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.