Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia

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• 作者：Lisa C. Lyons ; ^{lyons@bio.fsu.edu} ; Jacob S. Gardner ; Cassidy T. Lentsch ; Catherine E. Gandour ; Harini C. Krishnan ; Eric J. Noakes
• 关键词：Associative memory ; Learning ; Aplysia ; Calpain ; Protein kinase M ; Protein cleavage
• 刊名：Neurobiology of Learning and Memory
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：134-141
• 全文大小：531 K
• 卷排序：137

文摘

Inhibition of calpain activity with calpeptin or MDL-28170 prevented ITM formation. Calpain inhibition prior to training blocked the induction of LTM. Inhibiting calpain activity immediately after training impaired ITM but not LTM. Calpain activity at 6 h post-training is necessary for maintenance of 24 h LTM. Calpains function in multiple roles in associative memory formation.