Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens

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• 作者：Giulietta Maruggi^a ; ¹ ; ^{giulietta.x.maruggi@gsk.com} ; Emiliano Chiarot^a ; Cinzia Giovani^a ; Scilla Buccato^a ; Stefano Bonacci^a ; Elisabetta Frigimelica^a ; Immaculada Margarit^a ; Andrew Geall^b ; ² ; Giuliano Bensi^a ; Domenico Maione^a ; ^{domenico.x.maione@gsk.com}
• 关键词：Self-amplifying mRNA ; Protective immunity ; Vaccine ; SAM GBS ; GAS
• 刊名：Vaccine
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：35
• 期：2
• 页码：361-368
• 全文大小：842 K
• 卷排序：35

文摘

SAM vaccines were engineered to express prototype bacterial antigens from GAS and GBS. Mice immunized with both vaccines produced fully functional serum antibodies. Antibodies elicited by SAM vaccines conferred protection in mouse infection models. SAM vaccines have the potential to be used for a broad range of targets.