Gelatinases promote calcification of vascular smooth muscle cells by up-regulating bone morphogenetic protein-2

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Gelatinases promote calcification of vascular smooth muscle cells by up-regulating bone morphogenetic protein-2

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作者：Yong-Gang Zhao ^{zyg307@126.com" class="auth_mail" title="E-mail the corresponding author} ; Fan-Xing Meng ^{mfx2143@163.com" class="auth_mail" title="E-mail the corresponding author} ; Bing-Wei Li ^{drli715@163.com" class="auth_mail" title="E-mail the corresponding author} ; You-Ming Sheng ^{shengbiomed@163.com" class="auth_mail" title="E-mail the corresponding author} ; Ming-Ming Liu ^{mingmingliu@imc.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Bing Wang ^{bw20032007@126.com" class="auth_mail" title="E-mail the corresponding author} ; Hong-Wei Li ^{lihw66@imc.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Rui-Juan Xiu ; ^{xiurj@imc.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Vascular calcification ; Vascular smooth muscle cell ; Matrix metalloproteinase-2 ; Bone morphogenetic protein-2 ; Runt-related transcription factor 2
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：5 February 2016
年：2016
卷：470
期：2
页码：287-293
全文大小：1369 K

文摘

•: Gelatinases inhibition reduced calcification of cultured VSMCs.
•: Gelatinases inhibition attenuated phenotype transition of cultured VSMCs.
•: Gelatinases inhibition reduces calcification of VSMCs by down-regulating BMP-2.
•: Gelatinases are potential targets for treatment of vascular calcification.

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