Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis

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Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis

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作者：Athanasia Stathopoulou^a ; Dipa Natarajan^b ; ¹ ; Pinelopi Nikolopoulou^a ; Alexandra L. Patmanidi^a ; Zoi Lygerou^c ; Vassilis Pachnis^b ; Stavros Taraviras^a ; ^{taraviras@med.upatras.gr" class="auth_mail" title="E-mail the corresponding author}
关键词：Geminin ; Neural crest cells ; Self-renewal ; Differentiation ; Enteric nervous system
刊名：Developmental Biology
出版年：2016
出版时间：15 January 2016
年：2016
卷：409
期：2
页码：392-405
全文大小：15898 K

文摘

•: Geminin is expressed in migrating neural crest cells (NCCs) and their derivatives.
•: Geminin is essential for the generation of the enteric nervous system.
•: Enteric NCCs lacking Geminin show defects in self-renewal and increased apoptosis.
•: Deletion of Geminin from NCCs in mice leads to intestinal aganglionosis.

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