Nonstop-mRNA decay machinery is involved in the clearance of mRNA 5′-fragments produced by RNAi and NMD in Drosophila melanogaster cells

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Nonstop-mRNA decay machinery is involved in the clearance of mRNA 5′-fragments produced by RNAi and NMD in Drosophila melanogaster cells

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作者：Yoshifumi Hashimoto^a ; Masaki Takahashi^a ; Eri Sakota^a ; Yoshikazu Nakamura^a ; ^b ; ^{nak@ims.u-tokyo.ac.jp}
关键词：NSD ; Truncated nonstop mRNA ; Endonucleolytic cleavage ; RNAi
刊名：Biochemical and Biophysical Research Communications
出版年：2017
出版时间：26 February 2017
年：2017
卷：484
期：1
页码：1-7
全文大小：2045 K
卷排序：484

文摘

Pelota, Hbs1 and ABCE1 are crucially involved in NSD in Drosophila cells. Doubly knockdown of Pelota/Hbs1/ABCE1 depletes NSD in Drosophila cells. NSD pathway degrades mRNA 5′-fragments produced by RNAi and NMD.