Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

详细信息    查看全文

• 作者：Yi-Fen Lu¹ ; ² ; ³ ; Patrick Cahan¹ ; ² ; ³ ; ⁴ ; Samantha Ross¹ ; ³ ; Julie Sahalie¹ ; ³ ; Patricia M. Sousa¹ ; ³ ; Brandon K. Hadland⁵ ; ⁶ ; Wenqing Cai¹ ; Erik Serrao⁷ ; Alan N. Engelman⁷ ; Irwin D. Bernstein⁵ ; ⁶ ; George Q. Daley¹ ; ² ; ³ ; ⁸ ; ^{george.daley@childrens.harvard.edu}
• 关键词：hematopoietic stem cell ; HSC engineering ; ESC-HSC ; HoxB4 ; Notch ; adaptive immunity ; adult globin ; lineage-priming
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3178-3192
• 全文大小：6568 K
• 卷排序：17

文摘

Engineered HSCs can be made by co-expressing self-renewal and lineage-guiding factors Temporal and dosage control of Notch confers lymphoid potential in engineered HSCs Engineered HSCs reconstitute functional adaptive immune responses in vivo Individual engineered HSCs possess hybrid GRNs reflective of lineage priming