The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

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The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

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作者：Alessandra Pacini^a ; ^{lessandra.pacini@unifi.it" class="auth_mail" title="E-mail the corresponding author} ; Laura Micheli^b ; Mario Maresca^b ; Jacopo Juno Valerio Branca^a ; J. Michael McIntosh^c ; Carla Ghelardini^b ; Lorenzo Di Cesare Mannelli^b
关键词：Oxaliplatin ; Neuropathy ; α9α10 nAChRs selective antagonist ; RgIA ; CNS glial cells
刊名：Experimental Neurology
出版年：2016
出版时间：August 2016
年：2016
卷：282
期：Complete
页码：37-48
全文大小：2599 K

文摘

•: α-Conotoxin RgIA prevents oxaliplatin-induced pain threshold alterations.
•: α-Conotoxin RgIA counteracts PNS alterations induced by oxaliplatin.
•: RgIA relieves pain and nervous damage in the presence of glial cell activation.
•: RgIA is able, per se, to induce a significant increase in the CNS glial density.

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