Molecular epidemiology of influenza A (H5N1) viruses, Bangladesh, 2007-2011

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• 作者：Md. Ahasanul Hoque ; Hein Min Tun ; Mohammad Mahmudul Hassan ; Shahneaz Ali Khan ; SKM Azizul Islam ; Md. Nurul Islam ; Md. Giasuddin ; TABM Muzaffar Goni Osmani ; Ariful Islam ; Ronald Norman Thornton ; Graham William Burgess ; Lee Francis Skerratt ; Paul Selleck ; Edgar Brun ; Nitish Ch ; ra Debnath ; Frederick Chi-Ching Leung
• 关键词：Phylogenetic reconstruction ; Influenza A (H5N1)
• 刊名：Preventive Veterinary Medicine
• 出版年：2013
• 出版时间：1 September, 2013
• 年：2013
• 卷：111
• 期：3-4
• 页码：314-318
• 全文大小：704 K

文摘

To investigate the origins, evolution and patterns of spread of HPAI H5N1 outbreaks in Bangladesh, we performed a phylogenetic reconstruction analysis using Bayesian methods. The analysis was conducted using 81 hemagglutinin (HA) gene sequences from the H5N1 viruses isolated in Bangladesh from 2007 to 2011, together with 264 publicly available HA sequences of clade 2.2, 2.3.2 and 2.3.4 retrieved from GenBank. Our study provides evidence that clade 2.2.2 viruses that caused outbreaks in Bangladesh were lineages independent from the viruses introduced earlier into India. Furthermore, the Bangladesh clade 2.2.2 descendents subsequently spread to India and Bhutan. This has implications for avian influenza control in southern Asia suggesting multiple routes of entry of the virus including one pathway that spread to neighboring countries via Bangladesh.