Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms

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Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms

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作者：Hui Mei An^a ; ^b ; ¹ ; Yun Long Tan^a ; ^b ; ¹ ; Jing Shi^a ; ^b ; Zhi Ren Wang^a ; ^b ; Jia Li^a ; Yue Chan Wang^a ; Meng Han Lv^b ; Dong Feng Zhou^c ; Jair C. Soares^d ; Thoams R. Kosten^e ; Fu De Yang^a ; ^b ; ^{yfd200@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiang Yang Zhang^a ; ^b ; ^d ; ^{xiang.y.zhang@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Gingko biloba leaf extract ; Vitamin E ; Tardive dyskinesia ; S100B
刊名：Behavioural Brain Research
出版年：2016
出版时间：15 January 2016
年：2016
卷：297
期：Complete
页码：124-130
全文大小：1627 K

文摘

•: To compare the effects EGb761 with that of vitamin E for TD and S100B expression in four brain regions.
•: Both EGb761 and vitamin E significantly prevented the development of TD.
•: Both EGb761 and vitamin E significantly reversed the increased S100B in all studied brain regions.
•: Both EGb761 and vitamin E reduce TD symptoms, possibly via their effects on S100B signaling.

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